Details of the Drug

General Information of Drug (ID: DMAP8MV)

• Drug Name: Iron
• Synonyms: Eisen; Feronate; Ferretts; Ferrousal; Ferrum; Hemocyte; Hierro; LOHA; PZhO; Remko; Siderol; Yieronia; Ancor B; Armco iron; Carbonyl iron; Ferrous iron; Ferrovac E; Hoeganaes EH; Iron monocation; Iron standard for AAS; ATW 230; ATW 432; Atomel 28; Atomel 300M200; Atomel 500M; Atomel 95; Atomiron 44MR; Atomiron 5M; Atomiron AFP 25; Atomiron AFP 5; DSP 1000; DSP 128B; DSP 135; DSP 135C; DSP 138; EF 1000; EF 250; EFV 250; GS 6; HS 4849; Hoeganaes ATW 230; NC 100; PZh1M1; PZh2M; PZh2M1; PZh2M2; PZh3; PZh3M; PZh4M; Ancoren 80/150; Copy Powder CS 105-175; Diseases, iron overload; EFV 200/300; EFV 250/400; F 60 (metal); FT 3 (element); Fe-40; Fe1+; Ferro-Caps; Ferro-Time; HF 2 (element); HL (iron); HQ (metal); HS (iron); Iron (Fe); Iron(III) nitrate solution; Iron, elemental; PZh-1M3; PZh-2; SUY-B 2; Vitedyn-Slo; Diseases (animal), iron overload; Ed-In-Sol; Iron (Fe1+); Iron ion (Fe+); Iron ion(1+); Iron(1+); Iron(1+) ion; Iron, ion (Fe1+); Iron, ion (Fe1+) (8CI,9CI); 3ZhP

Indication

Disease Entry	ICD 11	Status	REF
Iron-deficiency anemia	3A00	Approved	[1]

• Therapeutic Class: Iron Supplement
• Drug Type: Small molecular drug
• #Ro5 Violations (Lipinski): 0:
  Molecular Weight; 55.84
  Topological Polar Surface Area; Not Available
  Rotatable Bond Count; 0
  Hydrogen Bond Donor Count; 0
  Hydrogen Bond Acceptor Count; 0
• Chemical Identifiers:
  Formula: Fe
  IUPAC Name: iron
  Canonical SMILES: [Fe]
  InChI: InChI=1S/Fe
  InChIKey: XEEYBQQBJWHFJM-UHFFFAOYSA-N
• Cross-matching ID:
  PubChem CID: 23925
  ChEBI ID: CHEBI:18248
  CAS Number: 7439-89-6
  DrugBank ID: DB01592
  TTD ID: D0Y3TM
  VARIDT ID: DR00317
  INTEDE ID: DR0882

Molecular Interaction Atlas of This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Hemoglobin (HB)	TTQO71U	HBA_HUMAN	Activator	[2]

Drug Transporter (DTP)

DTP Name	DTP ID	UniProt ID	MOA	REF
Sodium/bile acid cotransporter 7 (SLC10A7)	DTG1RJO	NTCP7_HUMAN	Substrate	[3]
Natural resistance-associated macrophage protein 2 (SLC11A2)	DTVKMHD	NRAM2_HUMAN	Substrate	[4]

Drug-Metabolizing Enzyme (DME)

DME Name	DME ID	UniProt ID	MOA	REF
Friedreich ataxia protein (FXN) Main DME	DEXVHDB	FRDA_HUMAN	Substrate	[5]

Drug-Drug Interaction (DDI) Information of This Drug

Coadministration of a Drug Treating the Disease Different from Iron (Comorbidity)

DDI Drug Name	DDI Drug ID	Severity	Mechanism	Comorbidity	REF
Sarecycline	DMLZNIQ	Moderate	Decreased absorption of Iron due to formation of complexes caused by Sarecycline .	Acne vulgaris [ED80]	[15]
ABT-492	DMJFD2I	Moderate	Decreased absorption of Iron due to formation of complexes caused by ABT-492.	Bacterial infection [1A00-1C4Z]	[16]
Omadacycline	DMR2J95	Moderate	Decreased absorption of Iron due to formation of complexes caused by Omadacycline.	Bacterial infection [1A00-1C4Z]	[15]
Dexlansoprazole	DM1DBV5	Moderate	Decreased absorption of Iron due to altered gastric pH caused by Dexlansoprazole.	Gastro-oesophageal reflux disease [DA22]	[17]
Dolutegravir	DMCZGRE	Major	Decreased absorption of Iron due to formation of complexes caused by Dolutegravir.	Human immunodeficiency virus disease [1C60-1C62]	[18]
Trientine	DMD2WPG	Moderate	Decreased absorption of Iron due to formation of complexes caused by Trientine.	Inborn metabolism deficiency [5C50-5C59]	[19]
Baloxavir marboxil	DM1UV7F	Moderate	Decreased absorption of Iron due to formation of complexes caused by Baloxavir marboxil.	Influenza [1E30-1E32]	[20]
Lanthanum carbonate	DMMJQSH	Moderate	Decreased absorption of Iron due to formation of complexes caused by Lanthanum carbonate.	Mineral absorption/transport disorder [5C64]	[21]
Eltrombopag	DMOGFIX	Moderate	Decreased absorption of Iron due to formation of complexes caused by Eltrombopag.	Thrombocytopenia [3B64]	[22]

References

• [1] Drug information of Iron, 2008. eduDrugs.
• [2] Efficacy and safety of total dose infusion of low molecular weight iron dextran in the treatment of iron deficiency anemia during pregnancy. J Coll Physicians Surg Pak. 2008 Jul;18(7):424-7.
• [3] Modulation of macrophage iron transport by Nramp1 (Slc11a1). Immunobiology. 2007;212(9-10):751-7.
• [4] Transmembrane topology of the mammalian Slc11a2 iron transporter. Biochemistry. 2009 Sep 8;48(35):8422-34.
• [5] Iron dysregulation in Friedreich ataxia. Semin Pediatr Neurol. 2006 Sep;13(3):166-75.
• [6] Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health Human Services. 2019
• [7] Blood substitutes- the polyheme trials. Mcgill J Med. 2008 January; 11(1): 59-65.
• [8] Increased oxygenation of intracranial tumors by efaproxyn (efaproxiral), an allosteric hemoglobin modifier: In vivo EPR oximetry study. Int J Radiat Oncol Biol Phys. 2005 Apr 1;61(5):1503-9.
• [9] Use of hemoglobin raffimer for postoperative life-threatening anemia in a Jehovah's Witness. Can J Anaesth. 2005 Apr;52(4):369-73.
• [10] A high-affinity fully human anti-IL-6 mAb, 1339, for the treatment of multiple myeloma. Clin Cancer Res. 2009 Dec 1;15(23):7144-52.
• [11] A phase 2 study of HQK-1001, an oral fetal haemoglobin inducer, in beta-thalassaemia intermedia. Br J Haematol. 2014 Feb;164(3):456-8.
• [12] 5-hydroxymethyl-2-furfural modifies intracellular sickle haemoglobin and inhibits sickling of red blood cells. Br J Haematol. 2005 Feb;128(4):552-61.
• [13] Modulating the oxygen affinity of human fetal haemoglobin with synthetic allosteric modulators. Br J Haematol. 1998 Sep;102(5):1165-71.
• [14] Clinical pipeline report, company report or official report of CRISPR Therapeutics.
• [15] Campbell NR, Hasinoff BB "Iron supplements: a common cause of drug interactions." Br J Clin Pharmacol 31 (1991): 251-5. [PMID: 2054263]
• [16] Nix DE, Wilton JH, Ronald B, Distlerath L, Williams VC, Norman A "Inhibition of norfloxacin absorption by antacids." Antimicrob Agents Chemother 34 (1990): 432-5. [PMID: 2334155]
• [17] Hutchison C, Geissler CA, Powell JJ, Bomford A "Proton pump inhibitors suppress absorption of dietary non-haem iron in hereditary haemochromatosis." Gut 56 (2007): 1291-5. [PMID: 17344278]
• [18] Product Information. Tivicay (dolutegravir). ViiV Healthcare, Research Triangle Park, NC.
• [19] Product Information. Syprine (trientine). Aton Pharma, Lawrenceville, NJ.
• [20] Cerner Multum, Inc. "Australian Product Information.".
• [21] Canadian Pharmacists Association.
• [22] Cerner Multum, Inc. "UK Summary of Product Characteristics.".